Job Description

Position Description

Our Company is seeking a creative, self-motivated computational chemist with exceptional interpersonal and problem-solving skills to join the Modeling and Informatics group at our West Point, PA site.

We are expanding our capability in computational medicinal chemistry and drug design to support our future organizational strategy for therapeutic discovery.

Modeling and Informatics is a sub-team of Discovery Chemistry, who employ state of the art capabilities in predictive sciences, AI/ML and structure-based drug design to accelerate our invention of therapeutics for patients.

We are an integral arm of both Discovery and Process Chemistry, and we collaborate seamlessly with teams across the globe to invent better molecules faster. With an unbiased approach to drug modalities, in-house access to the newest screening techniques, and world-class medicinal chemistry, we have a wealth of opportunities to impact our pipeline and ultimately save and improve patient lives.

The successful candidate will join multidisciplinary, highly collaborative discovery teams both locally and across our Company's global network to invent novel medicines. They will apply advanced computational techniques and develop innovative computational methods as necessary to solve problems in drug design.

Key responsibilities will include:

Design and optimization of drug candidates using advanced computational techniques as a member of discovery teams through:

• design of molecules utilizing existing our Company tools and techniques

• informative data analysis and visualization

• development of innovative computational workflows for molecular modeling

• protein construct design

• ligand library design

• application of AI/ML, generative modeling etc.

• Influencing teams in chemistry, and adjacent functionalities by effectively communicating non-obvious insights from computational approaches to drive project decisions and inflections

• Contributing to the overall wellbeing of our department by sharing knowledge, workflows, and being invested in the success of your peers.

Our organization is inspired by invention and founded on a culture of respect and collaboration. We recognize that the diversity in our team is our strength and are committed to creating an inclusive environment so that our employees can bring their whole selves to work. Successful candidates must demonstrate inclusive behaviors in working with a diverse group of scientists to drive our core mission. By joining us, you'll have the opportunity to expand your knowledge and skills through collaboration with talented and dedicated colleagues while contributing to developing medicines for human health.

Position Qualifications:

Education Minimum Requirement:

• PhD (or Master's degree + 7 years industrial experience) in biophysics, biochemistry, chemistry, engineering, or equivalent, with a computational emphasis.

Required Experience and Skills:

• 3 years of relevant experience in drug discovery industry (pharma or biotech) with a PhD, or 7 years of the same with a Master's degree.

• Demonstrated impact on molecule design in an industry environment

• A strong desire to learn and to innovate

• Evidence of creative application of computational approaches to problems of pharmaceutical interest

• Proficiency with modeling software packages (e.g. Schrodinger, MOE, Rosetta)

• Proficiency in general molecular modeling techniques (docking, molecular simulation, homology modeling, quantum mechanics, ligand- and structure-based design)

• Ability to communicate, collaborate and deliver results as a member of multi-disciplinary teams

• Ability to manage multiple priorities simultaneously

• Strong oral and written communication skills

• Track record of recent publications and/or presentations and external presence

Preferred Experience and Skills:

• Experience with Linux

• Skilled in scientific programming (e.g. Python, Pipeline Pilot) and data analytics (e.g. Spotfire, Pandas, Jupyter)

• Experience with QSAR, machine learning, deep learning

NB: Because we believe our best opportunity for impact on our pipeline involves in-person collaborations, this is an on-site position, it will not be remote work.

#computationalchemistry

#M&I

#eligibleforERP

Current Employees apply HERE

Current Contingent Workers apply HERE

US and Puerto Rico Residents Only:

Our company is committed to inclusion, ensuring that candidates can engage in a hiring process that exhibits their true capabilities. Please click here if you need an accommodation during the application or hiring process.

We are an Equal Opportunity Employer, committed to fostering an inclusive and diverse workplace. All qualified applicants will receive consideration for employment without regard to race, color, age, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, or disability status, or other applicable legally protected characteristics. For more information about personal rights under the U.S. Equal Opportunity Employment laws, visit:

EEOC Know Your Rights

EEOC GINA Supplement

Pay Transparency Nondiscrimination

We are proud to be a company that embraces the value of bringing diverse, talented, and committed people together. The fastest way to breakthrough innovation is when diverse ideas come together in an inclusive environment. We encourage our colleagues to respectfully challenge one another's thinking and approach problems collectively.

Learn more about your rights, including under California, Colorado and other US State Acts

U.S. Hybrid Work Model

Effective September 5, 2023, employees in office-based positions in the U.S. will be working a Hybrid work consisting of three total days on-site per week, Monday - Thursday, although the specific days may vary by site or organization, with Friday designated as a remote-working day, unless business critical tasks require an on-site presence.This Hybrid work model does not apply to, and daily in-person attendance is required for, field-based positions; facility-based, manufacturing-based, or research-based positions where the work to be performed is located at a Company site; positions covered by a collective-bargaining agreement (unless the agreement provides for hybrid work); or any other position for which the Company has determined the job requirements cannot be reasonably met working remotely. Please note, this Hybrid work model guidance also does not apply to roles that have been designated as "remote".

San Francisco Residents Only:We will consider qualified applicants with arrest and conviction records for employment in compliance with the San Francisco Fair Chance Ordinance

Los Angeles Residents Only:We will consider for employment all qualified applicants, including those with criminal histories, in a manner consistent with the requirements of applicable state and local laws, including the City of Los Angeles' Fair Chance Initiative for Hiring Ordinance

Search Firm Representatives Please Read Carefully
Merck & Co., Inc., Rahway, NJ, USA, also known as Merck Sharp & Dohme LLC, Rahway, NJ, USA, does not accept unsolicited assistance from search firms for employment opportunities. All CVs / resumes submitted by search firms to any employee at our company without a valid written search agreement in place for this position will be deemed the sole property of our company. No fee will be paid in the event a candidate is hired by our company as a result of an agency referral where no pre-existing agreement is in place. Where agency agreements are in place, introductions are position specific. Please, no phone calls or emails.

Employee Status:

Relocation:

VISA Sponsorship:

Travel Requirements:

Flexible Work Arrangements:

Shift:

Valid Driving License:

Hazardous Material(s):

Required Skills:

Preferred Skills:

Job Posting End Date:

*A job posting is effective until 11:59:59PM on the day BEFOREthe listed job posting end date. Please ensure you apply to a job posting no later than the day BEFORE the job posting end date.

Requisition ID:R328869